From mosaic to patchwork: matching lipids and proteins in membrane organization.

摘要: Biological membranes encompass and compartmentalize cells organelles are a prerequisite to life as we know it. One defining feature of is an astonishing diversity building blocks. The mechanisms principles organizing the thousands proteins lipids that make up membrane bilayers in still under debate. Many terms have been introduced over years account for certain phenomena aspects organization function. Recently, different viewpoints - focusing on vs. or physical molecular driving forces increasingly converging. Here review basic properties biological most common theories lateral segregation components before discussing emerging model self-organized, multi-domain 'patchwork membrane'.