Prognostic significance of the lymphocyte-to-monocyte ratio in patients with malignant pleural mesothelioma.
作者： Tomoko Yamagishi , Nobukazu Fujimoto , Hideyuki Nishi , Yosuke Miyamoto , Naofumi Hara
DOI: 10.1016/J.LUNGCAN.2015.07.014
关键词: Internal medicine 、 Oncology 、 Pathogenesis 、 Receiver operating characteristic 、 Lymphocyte 、 In patient 、 Multivariate analysis 、 Monocyte 、 Medicine 、 Mesothelioma 、 Pathology 、 Retrospective cohort study
摘要: Abstracts Objectives Chronic inflammation plays a key role in the pathogenesis of malignant pleural mesothelioma (MPM) as result asbestos exposure. Several inflammation-based prognostic scores including lymphocyte-to-monocyte ratio (LMR), Glasgow Prognostic Score (GPS), neutrophil-to-lymphocyte (NLR), and platelet-to-lymphocyte (PLR) reportedly predict survival many malignancies, while LMR MPM remains unclear. The aim this study was to evaluate clinical value compare these predicting overall (OS) MPM. Materials methods One hundred fifty patients with histologically proven were included retrospective study. Kaplan–Meier curves multivariate Cox-regression analyses calculated for OS. area under receiver operating characteristics curve (AUC) discriminatory ability each scoring system. Results An elevated significantly associated prolonged Patients p =0.000). consistently had higher AUC at 6 months (0.722), 12 (0.712), 24 (0.670), compared other scores. Multivariate analysis showed that independently Conclusions is an independent marker OS superior respect ability.
elsevier.com
sci-hub.se 参考文章(41)
Nico van Zandwijk, Stephen Clarke, Anthony Linton, Glen Reid, Christopher Cao, Steven Kao, Inflammation in malignant mesothelioma - friend or foe? Annals of cardiothoracic surgery. ,vol. 1, pp. 516- 522 ,(2012) , 10.3978/J.ISSN.2225-319X.2012.10.02
Jeffrey W. Pollard, Tumour-educated macrophages promote tumour progression and metastasis Nature Reviews Cancer. ,vol. 4, pp. 71- 78 ,(2004) , 10.1038/NRC1256
R. Cohen, Z. Steiner, A. Klajman, I. Bruderman, H. Rabinowich, Functional analysis of mononuclear cells infiltrating into tumors: lysis of autologous human tumor cells by cultured infiltrating lymphocytes. Cancer Research. ,vol. 47, pp. 173- 177 ,(1987)
Con Manganas, Tristan D. Yan, David Tian, Phoebe Matthews, Christopher Cao, Systematic review of trimodality therapy for patients with malignant pleural mesothelioma. Annals of cardiothoracic surgery. ,vol. 1, pp. 428- 437 ,(2012) , 10.3978/J.ISSN.2225-319X.2012.11.07
Lisa M. Coussens, Zena Werb, Inflammation and cancer Nature. ,vol. 420, pp. 860- 867 ,(2002) , 10.1038/NATURE01322
Marnix A Lameijer, Jun Tang, Matthias Nahrendorf, Robert HJ Beelen, Willem JM Mulder, None, Monocytes and macrophages as nanomedicinal targets for improved diagnosis and treatment of disease. Expert Review of Molecular Diagnostics. ,vol. 13, pp. 567- 580 ,(2013) , 10.1586/14737159.2013.819216
Dario Bugada, Massimo Allegri, Patricia Lavand'homme, Marc De Kock, Guido Fanelli, Inflammation-based scores: a new method for patient-targeted strategies and improved perioperative outcome in cancer patients. BioMed Research International. ,vol. 2014, pp. 142425- 142425 ,(2014) , 10.1155/2014/142425
LA Lievense, Koen Bezemer, JGJV Aerts, JPJJ Hegmans, None, Tumor-associated macrophages in thoracic malignancies Lung Cancer. ,vol. 80, pp. 256- 262 ,(2013) , 10.1016/J.LUNGCAN.2013.02.017
Jing Li, Rou Jiang, Wen-Sheng Liu, Qing Liu, Miao Xu, Qi-Sheng Feng, Li-Zhen Chen, Jin-Xin Bei, Ming-Yuan Chen, Yi-Xin Zeng, A Large Cohort Study Reveals the Association of Elevated Peripheral Blood Lymphocyte-to-Monocyte Ratio with Favorable Prognosis in Nasopharyngeal Carcinoma PLoS ONE. ,vol. 8, pp. e83069- ,(2013) , 10.1371/JOURNAL.PONE.0083069
Donald C. McMillan, The systemic inflammation-based Glasgow Prognostic Score: a decade of experience in patients with cancer. Cancer Treatment Reviews. ,vol. 39, pp. 534- 540 ,(2013) , 10.1016/J.CTRV.2012.08.003