The role of blood-brain barrier transporters in pathophysiology and pharmacotherapy of stroke.

摘要: Abstract Cerebral ischemia is one of the major causes disability worldwide. In cerebral ischemic stroke, occlusion a artery by an embolus or local thrombosis can result in transient permanent reduction blood flow to portion brain, resulting deprivation glucose and oxygen. Since brain relies on continuous supply nutrients ions via mostly carrier mediated processes across blood-brain barrier (BBB), any irregularity these transport mechanisms dramatically affects neuronal function outcome after acute chronic stroke. Despite numerous encouraging breakthroughs preclinical stroke studies that evaluate monotherapies prevailing neurocentric approach has yielded disappointing clinical translation, investigating additional therapeutic targets might be used more effectively combination with thrombolysis. this context, current review discusses understanding dysfunctionional BBB nutrient ion involved pathophsyiology as novel approaches. Recognition important role neurovascular unit pathophysiology will provide new opportunities treat injury, maintenance ionic homeostasis should facilitate repair