Neuroprotectives in Acute Ischemic Stroke, Hope or Hype?

摘要: Stroke is a significant public health burden which absolutely requires more effective therapies. The approved treatment options for stroke including tissue plasminogen activators, antiplatelet agents and anticoagulants mainly bear antithrombotic effects. Meanwhile, evolving investigational approaches such as collateral therapeutics neuroprotective has thus far been attempted with equivocal effects on outcome. basic structural ultrastructural changes following acute ischemic should be well-considered when trying to target oxidative stress cell death pathways using agents. Clearly, the positive results of preclinical studies neuroprotectives in do not necessarily translate true clinical benefits these As such, several large advance-phased trials have already failed prove so. On other hand, controversial setting discourage further research endeavors same. Besides, concurrent use flow augmentation may serve benefits. Based available evidence, it appears that optimization well-designed prospective let neuroprotection possibly find its position management.  present paper discusses key towards improved outcome stroke.