Absolute monocyte/lymphocyte count prognostic score is independent of immunohistochemically determined cell of origin in predicting survival in diffuse large B-cell lymphoma.
作者： Luis F. Porrata , Kay Ristow , Thomas M. Habermann , Nazan Ozsan , Ahmet Dogan
DOI: 10.3109/10428194.2012.690605
关键词: Lymphoma 、 Univariate analysis 、 Oncology 、 Pathology 、 Diffuse large B-cell lymphoma 、 Internal medicine 、 International Prognostic Index 、 Lymphocyte 、 Cohort 、 Multivariate analysis 、 Proportional hazards model 、 Medicine
摘要: The absolute monocyte/lymphocyte count prognostic score (AMC/ALC score) has not been directly compared with the cell of origin (COO) to predict overall survival (OS) and progression-free (PFS) in diffuse large B-cell lymphoma (DLBCL). Thus, we retrospectively examined a new cohort 99 patients DLBCL treated from 2008 2010, (1) validate whether AMC/ALC affects survival, (2) investigate is independent COO (3) assess can further stratify clinical outcomes by COO. By univariate analysis, was predictor for OS PFS. On multivariate analysis performed including International Prognostic Index, remained an able added its ability identify high-risk disease.
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