Quantitative multispectral biosensing and 1D imaging using quasi-3D plasmonic crystals

作者: M. E. Stewart , N. H. Mack , V. Malyarchuk , J. A. N. T. Soares , T.-W. Lee

DOI: 10.1073/PNAS.0606216103

关键词: Multispectral imageNanoimprint lithographyMolecular bindingNanotechnologyMicrometreMaterials scienceMicrofluidicsSurface plasmonImage resolutionPlasmon

摘要: We developed a class of quasi-3D plasmonic crystal that consists multilayered, regular arrays subwavelength metal nanostructures. The complex, highly sensitive structure the optical transmission spectra these crystals makes them especially well suited for sensing applications. Coupled with quantitative electrodynamics modeling their response, they enable full multiwavelength spectroscopic detection molecular binding events sensitivities correspond to small fractions monolayer. high degree spatial uniformity crystals, formed by soft nanoimprint technique, provides ability image over large areas micrometer resolution. These features, together compact form factors, low-cost fabrication procedures, simple readout apparatus, and direct integration into microfluidic networks arrays, suggest promise devices in label-free bioanalytical systems.

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