Natural antisense transcripts in fungi.

作者: Michael E. Donaldson , Barry J. Saville

DOI: 10.1111/J.1365-2958.2012.08125.X

关键词: BiologyNatChromatin remodellingComputational biologySexual reproductionRNA silencingIdentification (biology)TranscriptomeContext (language use)GeneticsGene expression

摘要: Summary Fungi are models for investigating many eukaryotic molecular processes. The identification of natural antisense transcripts (NATs) in fungi led to the discovery mechanisms controlling gene expression through transcriptional interference, chromatin remodelling and dsRNA formation. An overview these description specific NAT functions is provided give context a broader discussion fungal NATs. Transcriptome analyses have revealed large number NATs divergent group fungi. timing suggests roles core life functions, such as responding environment sexual reproduction. transcriptome studies also uncover whose remain elusive. These could provide novel control expression, targeted responses stimuli, or other functions. goal this review background expanding field research while highlighting opportunities future discoveries.

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