Synthesis of quinone imine and sulphur-containing compounds with antitumor and trypanocidal activities: redox and biological implications

摘要: Ortho-Quinones represent a special class of redox active compounds associated with spectrum pronounced biological activities, including selective cytotoxicity and antimicrobial actions. The modification the quinone ring by simple nitrogen sulphur substitutions leads to several new classes their own, distinct behaviour equally activities against cancer cell lines Trypanosoma cruzi. Some investigated show activity T. cruzi at concentrations 24.3 65.6 μM selectivity index around 1. These results demonstrate that chemical modifications on ortho-quinone system, in particular, heteroatoms such as sulphur, transform these molecules into powerful cytotoxic agents considerable “potential”, not only synthesis electrochemistry, but also, broader sense, health sciences.