Enhancement of gastrointestinal absorption of quercetin by solid lipid nanoparticles.

摘要: The aim of the present study is to design and characterize quercetin-loaded solid lipid nanoparticles (QT-SLNs), clarify absorption mechanism QT-SLNs evaluate potential using (SLNs) as an oral delivery carrier for poorly water soluble drugs. were prepared by emulsification low-temperature solidification method. presented spherically shaped under transmission electron microscopy, with average diameter 155.3 nm. drug entrapment efficiency, loading zeta 91.1%, 13.2% -32.2 mV, respectively. Drug release from was fitted a double phase kinetics model equation follows: 100-Q=98.87e(-0.1042t)+42.45e(-0.0258t). in gastrointestinal (GI) tract studied situ perfusion method rats. It found that percent stomach 2 h only 6.20%, process intestine first-process passive diffusion mechanism, main absorptive segments ileum colon. A pharmacokinetic conducted rats after administration quercetin at 50 mg/kg form either or suspension. plasma concentration-time curves both one-compartment model. relative bioavailability suspension 571.4%. T(max) MRT delayed. Our studies provide evidence SLNs are valuable enhance drug, quercetin.