Triazole derivatives which are smo antagonists
作者： Rolf Thieringer , Sherman T. Waddell , James M. Balkovec
DOI:
关键词: Chemistry 、 Hydrogen 、 Salt (chemistry) 、 Triazole derivatives 、 Oxygen atom 、 Fluorine 、 Medicinal chemistry 、 Stereochemistry 、 Ring (chemistry)
摘要: The present invention provides a method for the treatment or prevention of conditions which can be ameliorated by Smo antagonism, comprises administration to patient in need thereof an effective amount compound formula I composition comprising I: pharmaceutically acceptable salt solvate thereof; wherein: 2 X, Y and Z represent nitrogen atoms, other represents oxygen atom; R1 R2 are taken together with atom they attached cyclobutyl ring, optionally substituted 1-2 fluorine R3 hydrogen methyl, methyl atom.
lens.org 参考文章(10)
Anssi J. Taipale, James K. Chen, Philip A. Beachy, Hedgehog pathway antagonists ,(2004)
Steven H. Olson, Yuping Zhu, James M. Balkovec, 11-beta-hydroxysteroid dehydrogenase 1 inhibitors useful for the treatment of diabetes, obesity and dyslipidemia ,(2003)
Janet L. Gunzner, Georgette Castanedo, Daniel P. Sutherlin, Michael S. Dina, Shumei Wang, Scott J. Savage, Liang Bao, Kimberly Malesky, Mark S. Stanley, Mark E. Reynolds, Rebecca L. Lalonde, Pyridyl inhibitors of hedgehog signalling ,(2005)
Susan D. Aster, Gina M. Santorelli, Aaron H. Leeman, Milana M. Maletic, Sherman T. Waddell, Xin Gu, James M. Balkovec, Donald W. Graham, Triazole derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase-1 ,(2003)
Gina M. Santorelli, Aaron H. Leeman, Milana Maletic, Sherman T. Waddell, Xin Gu, James M. Balkovec, Sulfonyl compounds as inhibitors of 11-beta-hydroxysteroid dehydrogenase-1 ,(2005)
Xu Wu, Dai Cheng, Dong Han, Shifeng Pan, Wenqi Gao, Yongqin Wan, Jiqing Jiang, Compounds and compositions as hedgehog pathway modulators ,(2007)
Michael A. Foley, Martin R. Tremblay, Julian Adams, Somarajan Nair Janardanan Nair, Alfredo C. Castro, James R. Porter, Marta Nevalainen, Cyclopamine analogues and methods of use thereof ,(2005)
Oivin M. Guicherit, Anthony David Argenta Discovery Ltd. Baxter, Lee L. Rubin, Edward Anthony Evotec Oai Ltd. Boyd, Stephen Argenta Discovery Ltd. Price, Mediators of hedgehog signaling pathways, compositions and uses related thereto ,(2000)
Xin Gu, Jasminka Dragovic, Gloria C. Koo, Sam L. Koprak, Cheryl LeGrand, Steven S. Mundt, Kashmira Shah, Marty S. Springer, Eugene Y. Tan, Rolf Thieringer, Anne Hermanowski-Vosatka, Hratch J. Zokian, James M. Balkovec, Sherman T. Waddell, Discovery of 4-heteroarylbicyclo[2.2.2]octyltriazoles as potent and selective inhibitors of 11β-HSD1: Novel therapeutic agents for the treatment of metabolic syndrome Bioorganic & Medicinal Chemistry Letters. ,vol. 15, pp. 5266- 5269 ,(2005) , 10.1016/J.BMCL.2005.08.052
Daniel P. Sutherlin, Michael F. T. Koehler, Richard Goldsmith, Quinoxaline inhibitors of the hedgehog signalling pathway ,(2005)