Synthesis, characterization and in vitro anti-tumor activities of matrine derivatives.
作者： Lisheng Wang , Yejun You , Songqing Wang , Xu Liu , Buming Liu
DOI: 10.1016/J.BMCL.2012.04.069
关键词: Chemistry 、 Biochemistry 、 Structure–activity relationship 、 Stereochemistry 、 Matrine 、 Infrared spectroscopy 、 In vitro 、 Nuclear magnetic resonance spectroscopy 、 Cell culture 、 Proton NMR 、 Colchicine
摘要: Nineteen previously unreported matrine derivatives were synthesized and characterized using elemental analysis, infrared spectroscopy, proton nuclear magnetic resonance mass spectrometry. Target compounds 6a-6l 7a-7c showed stronger inhibitory activities than in the vitro antitumor tests inhibited growth of Hep7402, B16-F10, A549, TW03 cell lines. In addition, compound 6i exhibited a potent activity similar to that colchicine.
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