Protective immunity to experimental tuberculosis by mannophosphoinositides of mycobacteria.
作者： P.K. Mehta , GopalK. Khuller
DOI: 10.1007/BF00189412
关键词: Biology 、 Tuberculosis 、 Immunization 、 Mycobacterium tuberculosis 、 Spleen 、 Immunology 、 Bovine serum albumin 、 Immune system 、 Serum albumin 、 Colony-forming unit
摘要: Mannophosphoinositides isolated from mycobacterial cells were found to induce both humoral and cell-mediated immune responses in mice when injected as mannoside-methylated bovine serum albumin (MBSA) complexes. Immunization of with mannoside-MBSA complexes elicited significant protection against challenge LD50 dose M. tuberculosis H37Rv revealed by high survival rate, low values root-specific lung weight, densities colony forming units recovered lung, liver spleen, compared the nonimmunized group. These observations further substantiated histopathological studies. The protective immunity was mediated cooperation T-B cells, shown passive transfer cells/sera into syngeneic sublethally irradiated recipient mice.
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