Effect of low alcohol dose on behavioral "despair" in rats neonatally treated with antidepressant drugs.
作者： Julio Fernandez-Pardal , Leena A. Hilakivi
DOI: 10.1016/0741-8329(89)90031-1
关键词: Internal medicine 、 Anesthesia 、 Endocrinology 、 Ethanol 、 Monoamine neurotransmitter 、 Psychology 、 Nomifensine 、 Imipramine 、 Learned helplessness 、 Desipramine 、 Alcohol 、 Antidepressant
摘要: Abstract Rat pups were treated with monoamine uptake inhibiting antidepressant drugs, desipramine, imipramine or nomifensine (5 mg/kg) during the second and third postnatal weeks, their later behavioral “despair,” measured by Porsolt's swim test, was examined. At age of two months, desipramine-treated rats showed lengthened immobility in thus probably increased “despair.” They also responded to 1 g/kg alcohol shortening level control rats. Neonatal treatment either did not affect test behavior. The results suggest that a low, stimulatory dose able reverse desipramine early period.
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