Homing potentials of circulating antibody-secreting cells after administration of oral or parenteral protein or polysaccharide vaccine in humans
作者： Anu Kantele , Mia Westerholm , Jussi M. Kantele , P.Helena Mäkelä , Erkki Savilahti
DOI: 10.1016/S0264-410X(98)00193-5
关键词: Immunology 、 Microbiology 、 Homing (hematopoietic) 、 Antibody 、 Cholera vaccine 、 Polysaccharide Vaccine 、 Lymphocyte homing receptor 、 Biology 、 Antigen 、 Immune system 、 Ty21a
摘要: Abstract The site of antigen encounter influences the Ig-distribution and homing potentials circulating antibody-secreting cells (ASC) induced. After oral administration, majority ASC secrete mucosal Ig-isotype, IgA, all them express gut receptor (HR), α 4 β 7 , thus implying these cells. Parenteral protein vaccine induces an IgG-dominated response with a low proportion expressing However, polysaccharide vaccine, even if administered parenterally, elicits IgA-dominated response, hence suggesting to mucosa. In order study influence nature on targeting present work compares in humans after administration Salmonella Typhi Ty21a (antigen studied: O-9,12 polysaccharide), recombinant cholera toxin B-subunit, CTB protein), parenteral pneumococcal Pnc capsular 19F) or tetanus toxoid TT protein). was expressed higher induced by (99%) than (70%) (63%). l -selectin, peripheral lymph node HR, smaller (37%) (43%) those (78%) (81%). results imply that has profound effect it does not seem response.
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