The Histopathology of braf -v600e–mutated Lung Adenocarcinoma

摘要: BRAF mutations in lung adenocarcinoma are much less common than the more frequently reported and mutually exclusive of KRAS EGFR genes, clinical histologic phenotype adenocarcinomas has not been described. We analyzed 222 lacking identified 10 with BRAF-V600E mutation. All were heterozygous. There was a slight female predilection (6:4) these elderly patients (average age 67 y) who found to have greater expected incidence intralobar satellite nodules N2 node involvement. The largely mixed type high papillary (80%) lepidic growth (50%). Adenocarcinomas this clinicopathologic may be worthwhile investigating for mutation as genetically oriented drug therapies emerge.