Focal chromosomal copy number aberrations in cancer—Needles in a genome haystack
作者： Oscar Krijgsman , Beatriz Carvalho , Gerrit A. Meijer , Renske D.M. Steenbergen , Bauke Ylstra
DOI: 10.1016/J.BBAMCR.2014.08.001
关键词: Genome 、 Gene 、 Single gene 、 Copy-number variation 、 Genomics 、 Haystack 、 Biology 、 Cancer 、 Genetics 、 Copy number aberration
摘要: The extent of focal chromosomal copy number aberrations (CNAs) in cancer has been uncovered through technical innovations, and this discovery critical for the identification new driver genes genomics projects such as TCGA ICGC. Unlike constitutive variations (CNVs), CNAs are result many selection events during evolution genomes. Therefore, it is possible that a single gene CNA gives tumor selective growth advantage. This concept instrumental genes. However, lack consensus definition; therefore, we propose one based on pragmatic considerations. We also describe different strategies to identify procedures distinguish them from large CNVs.
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