Focal Chromosomal Copy Number Aberrations Identify CMTM8 and GPR177 as New Candidate Driver Genes in Osteosarcoma

摘要: Osteosarcoma is an aggressive bone tumor that preferentially develops in adolescents. The characterized by abundance of genomic aberrations, which hampers the identification driver genes involved osteosarcoma tumorigenesis. Our study aims to identify these investigation focal copy number aberrations (CNAs, <3 Mb). For this purpose, we subjected 26 primary tumors patients high-resolution single nucleotide polymorphism array analyses and identified 139 somatic CNAs. Of these, 72 had at least one gene located within or overlapping CNA, with a total 94 genes. 84 genes, expression status 31 samples was determined microarray analysis. This enabled us over- underexpression more than 35% cases accordance their (gain loss). These candidate were subsequently validated independent set furthermore corroborated as verifying role other types. We CMTM8 new suppressor GPR177 oncogene osteosarcoma. In osteosarcoma, has been shown suppress EGFR signaling. types, known activity oncogenic protein c-Met overexpressed upstream regulator Wnt-pathway. Further studies are needed determine whether proteins also exert latter functions