Phenotypic characteristics of human monocytes undergoing transendothelial migration.
作者： Johannes Grisar , Philipp Hahn , Susanne Brosch , Meinrad Peterlik , Josef S Smolen
DOI: 10.1186/AR150
关键词: Endothelium 、 Phenotype 、 Immunophenotyping 、 Monocyte 、 Cell biology 、 CD11a 、 Inflammation 、 Endothelial stem cell 、 Cytokine 、 Biology
摘要: In our study we characterised the immunophenotype of monocytes that migrated through an endothelial cell (EC) monolayer in vitro. We found monocyte migration led to enhanced expression CD11a, CD33, CD45RO, CD54 [intercellular cell-adhesion molecule (ICAM)-1] and human leucocyte antigen-DR. The most striking increase was observed for ICAM-1 when ECs were activated with tumour necrosis factor-α interleukin-1α. results indicate following: (1) there is a characteristic on surface after transendothelial migration; (2) this phenotype seems be induced by interactions between ECs; (3) change pretreatment cytokines. Taken together, suggest local cytokine production activating sufficient enhance this, turn, can induce changes consistent known interactive antigen-presenting cells T cells. These have implications pathogenetic insights into rheumatoid arthritis.
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