On-line calorimetry as a technique for process monitoring and control in biotechnology
作者： Urs von Stockar , Philippe Duboc , Laurent Menoud , I.W. Marison
DOI: 10.1016/S0040-6031(97)00055-5
关键词: Metabolic state 、 Monitoring and control 、 Bioreactor 、 Biochemical engineering 、 Heat generation 、 Instrumentation (computer programming) 、 Computer science 、 Scientific method 、 Calorimetry
摘要: A review with 29 refs. of lab.-scale investigations carried out on the usefulness biol. heat-release measurements, as a means for monitoring and controlling metabolic state microbial cultures. Such studies are in high-quality bench-scale calorimeters, but measuring heat generation rates by establishing energy balances ought to be applicable large-scale bioreactors without resorting sophisticated instrumentation. The signal received can either interpreted more qual. correlation evolution culture, or it may quant. exploited -together other online measurements - order assess at which various types metabs. proceed culture. work described shows how this used keep culture desired during fed-batch transient continuous cultures yeast, S. cerevisae, bacterial controlled optimize biosynthesis an antibiotic. [on SciFinder (R)]
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