Modeling cell shape and dynamics on micropatterns

摘要: Adhesive micropatterns have become a standard tool to study cells under defined conditions. Applications range from controlling the differentiation and fate of single guiding collective migration cell sheets. In long-term experiments, normalization is challenged by division. For all these setups, mathematical models predicting shape dynamics can guide pattern design. Here we review recent advances in explaining shape, traction forces on micropatterns. Starting with contour as simplest approach explain concave shapes, move network continuum descriptions examples for static models. To describe dynamic processes, cellular Potts, vertex phase field be used. Different types model are appropriate address different biological questions together, they provide versatile box predict behavior