Development of Systems for Targeting the Regional Lymph Nodes for Diagnostic Imaging: In Vivo Behaviour of Colloidal PEG-Coated Magnetite Nanospheres in the Rat Following Interstitial Administration
作者： L. Illum , A. E. Church , M. D. Butterworth , A. Arien , J. Whetstone
关键词: In vivo 、 Biomedical engineering 、 Lymph node 、 Surgery 、 Drug carrier 、 In vitro 、 Ethylene glycol 、 Chemistry 、 Lymph 、 Surface modification 、 PEG ratio
摘要: Purpose. Nanoparticles can be utilised for targeting drugs to the regional lymph nodes or as diagnostic agents. The surface modification of magnetite nanospheres with poly(ethylene glycol) (PEG) has been assessed by in vitro characterisation and vivo studies following subcutaneous administration rat.
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