Carcinostatic action of polycarbonyl compounds and their derivatives. I. 3-Ethoxy-2-ketobutyraldehyde and related compounds.
作者： Frederic A. French , B. L. Freedlander
DOI:
关键词: Leukemia L1210 、 Alkoxy group 、 Medicinal chemistry 、 Succinaldehyde 、 Chemistry 、 Polycarbonyl 、 Life span 、 Glyoxal
摘要: Summary 1.3-Ethoxy-2-ketobutyraldehyde (Kethoxal®) increases, consistently, the life span of mice with Leukemia L1210. 2.Phenylglyoxal, cyclohexylglyoxal, methoxy-methylglyoxal, glyoxal, succinaldehyde, and malonaldehyde also showed some antileukemic activity. 3.Relationships among structure, activity, side effects are discussed.
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