Radiographic assessment and therapeutic decisions at RECIST progression in EGFR-mutant NSCLC treated with EGFR tyrosine kinase inhibitors
作者： Mizuki Nishino , Stephanie Cardarella , Suzanne E. Dahlberg , David M. Jackman , Nikhil H. Ramaiya
DOI: 10.1016/J.LUNGCAN.2012.11.007
关键词: Cancer research 、 Neoplasm 、 Epidermal growth factor receptor 、 Carcinoma 、 Lung cancer 、 Clinical trial 、 Mutant 、 Drug resistance 、 Medicine 、 Progressive disease
摘要: Purpose Advanced NSCLC harboring epidermal growth factor receptor (EGFR) mutations treated with EGFR tyrosine kinase inhibitors (TKIs) typically progresses after initial response due to acquired resistance. TKIs are often continued beyond progressive disease by RECIST. We investigated the practice of continuing EGFR-TKIs RECIST-PD via CT findings.
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