Preparation and characterization of a biodegradable drug targeting system for anticancer drug delivery: microsphere-antibody conjugate.
作者： Asli Muvaffak , Ismet Gurhan , Ufuk Gunduz , Nesrin Hasirci
DOI: 10.1080/10611860400029069
关键词: Targeted drug delivery 、 Conjugate 、 Drug carrier 、 Drug 、 Chemistry 、 Pharmacology 、 Therapeutic index 、 Methotrexate 、 Gelatin 、 Serum albumin
摘要: Targeted delivery of anticancer drugs is one the most actively pursued goals in chemotherapy. A major disadvantage their lack selectivity for tumour tissue, which causes severe side effects and results low cure rates. Any strategy by a cytotoxic drug targeted to tumour, thus increasing therapeutic index drug, way improving cancer chemotherapy minimizing systematic toxicity. This study covers preparation gelatin microsphere (GM)-anti-bovine serum albumin (anti-BSA) conjugate development targeting approach delivery. Microspheres 5% (w/v) content were prepared crosslinking with glutaraldehyde (GTA) at 0.05 0.50% (v/v) concentration. size range 71–141 μm. The suitability these microspheres as carriers was investigated vitro studying release profiles loaded methotrexate (MTX) 5-fluorour...
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