Effects of fenofibrate on high-fat diet-induced body weight gain and adiposity in female C57BL/6J mice.

摘要: Abstract Our previous study suggested that fenofibrate affects obesity and lipid metabolism in a sexually dimorphic manner part through the differential activation of hepatic peroxisome proliferator-activated receptor α (PPARα) male female C57BL/6J mice. To determine whether reduces body weight gain adiposity sham-operated (Sham) ovariectomized (OVX) mice, effects on not only weight, white adipose tissue (WAT) mass, food intake, but also expression both leptin PPARα target genes were measured. Compared to their respective low-fat diet-fed controls, Sham OVX mice exhibited increases WAT mass when fed high-fat diet. Fenofibrate treatment decreased OVX, Furthermore, increased mRNA levels encoding peroxisomal enzymes involved fatty acid β-oxidation, reduced apolipoprotein C-III (apo C-III) mRNA, all which expressed at higher compared However, found positively correlate with intake was changed either or following treatment. These results suggest differentially regulates due differences activation, production, between