An efficient multiplex genotyping approach for detecting the major worldwide human Y-chromosome haplogroups
作者： Mannis van Oven , Arwin Ralf , Manfred Kayser
DOI: 10.1007/S00414-011-0605-2
关键词: Human population genetics 、 Genetics 、 Evolutionary biology 、 Y-SNP 、 Phylogenetic tree 、 Genotype 、 Y chromosome 、 Haplogroup 、 Haplotype 、 Amplicon 、 Biology
摘要: The Y chromosome is paternally inherited and therefore serves as an evolutionary marker of patrilineal descent. Worldwide DNA variation within the non-recombining portion can be represented a monophyletic phylogenetic tree in which branches (haplogroups) are defined by at least one SNP. Previous human population genetics research has produced wealth knowledge about worldwide distribution Y-SNP haplogroups. Here, we apply previous very recent on phylogeny Y-haplogroup introducing two multiplex genotyping assays that allow for hierarchical detection 28 Y-SNPs defining major PCR amplicons were kept small to make method sensitive thereby applicable limited amount and/or quality such forensic settings. These thus form valuable tool researchers fields genetic anthropology infer man's bio-geographic ancestry from DNA.
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