The X Files: “The Mystery of X Chromosome Instability in Alzheimer’s Disease”
作者： Vladan P. Bajic , Magbubah Essack , Lada Zivkovic , Alan Stewart , Sonja Zafirovic
关键词: Genetics 、 Chromosome 21 、 Disease 、 Epigenetics 、 X chromosome 、 Genome-wide association study 、 Amyloid precursor protein 、 Gene 、 Biology 、 Genetic risk
摘要: Alzheimer's disease (AD) is a neurodegenerative that affects millions of individuals worldwide and can occur relatively early or later in life. It well known genetic components, such as the amyloid precursor protein gene on chromosome 21, are fundamental early-onset AD (EOAD). To date, however, only apolipoprotein E4 (ApoE4) has been proved to be risk factor for late-onset (LOAD). In recent years, despite hypothesis many additional unidentified genes likely play role development, it surprising polymorphisms associated with LOAD have failed come light. this review, we examine X epigenetics and, based upon GWAS studies, PCDHX11 gene. Furthermore, explore other factors involve X-chromosome epigenetics.
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