Regulation of DNA repair by ubiquitylation
作者： Tony T. Huang , Alan D. D'Andrea
DOI: 10.1038/NRM1908
关键词: Proteasome 、 Ubiquitin 、 DNA synthesis 、 Homologous recombination 、 Cell biology 、 Biology 、 Extramural 、 DNA repair 、 DNA damage 、 DNA biosynthesis
摘要: The process of ubiquitylation is best known for its role in targeting proteins degradation by the proteasome. However, recent studies DNA-repair and DNA-damage-response pathways have significantly broadened scope to include non-proteolytic functions ubiquitin. These involve monoubiquitylation key that regulatory homologous recombination translesion DNA synthesis, polyubiquitylation nucleotide-excision-repair proteins.
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