4-Phenylpyridine derivatives and their use as NK-1 receptor antagonists
作者： Thierry Godel , Walter Hunkeler , Guido Galley , Michael Montreal Boes , Patrick Schnider
DOI:
关键词: Alkoxy group 、 Chemistry 、 Tertiary amine 、 Hydrogen 、 Trifluoromethyl 、 Halogen 、 Alkyl 、 NK 1 Receptor Antagonists 、 Stereochemistry
摘要: The invention relates to compounds of formula (I) wherein R is hydrogen, lower alkyl, alkoxy, halogen or trifluoromethyl; R1 hydrogen halogen; and may be together -CH=CH-CH=CH-; R2 halogen, trifluoromethyl, alkoxy cyano; R3 alkyl form a cycloalkyl group; R4 -N(R5)2, -N(R5)S(O)2-lower -N(R?5)C(O)R5? cyclic tertiary amine the group (a); R5 is, independently from each other, C?3-6?-cycloalkyl, benzyl alkyl; R?6? hydroxy, -N(R5)CO-lower hydroxy-lower cyano, -CHO 5- 6 membered heterocyclic group, optionally bonded via an alkylene X -C(O)N(R5)-, -(CH?2?)mO-, -(CH2)mN(R?5?)-, -N(R5)C(O)-, -N(R5)(CH2)m-; n 0-4; m 1 2; pharmaceutically acceptable acid addition salts thereof. It has been shown that above mentioned have good affinity NK-1 receptor.
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