2-(3,5-bis-trifluoromethyl-phenyl)-n-methyl-n-(6-morpholin-4-yl-4-o-tolyl-pyridin-3-yl)-isobutyramide

作者: Andrew Sleight , Sonia Maria Poli , Theresa Maria Ballard , Torsten Hoffmann , Guy Andrew Higgins

DOI:

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摘要: The invention relates to the compound of formula (see I) which is 2-(3,5-bis-trifluoromethyl-phenyl)-N-methyl-N-(6-morpholin-4-yl-4-o- tolyl- pyridin-3-yl)-isobutyramide. It has been found that this a high affinity NK- 1 receptor and it therefore useful in treatment diseases, relate receptor.

参考文章(3)
Hideaki Natsugari, Yoshinori Ikeura, Chiharu Kimura, Takayuki Doi, Takenori Ishimaru, Cyclic compounds, their production and use as tachykinin receptor antagonists ,(1996)
Thierry Godel, Walter Hunkeler, Guido Galley, Michael Montreal Boes, Patrick Schnider, Heinz Stadler, Quirico Branca, Torsten Hoffmann, 4-Phenylpyridine derivatives and their use as NK-1 receptor antagonists ,(2000)