Use of nk-1 receptor antagonists with pyridinic structure, for the treatment of brain, spinal or nerve injury

摘要: The invention relates to the use of an NK-1 receptor antagonist, optionally in combination with a magnesium salt, for treatment and/or prevention brain, spinal or nerve injury, wherein said NK-l antagonist is compound general formula (I) meanings R, R?1, R2, R2', R3, R4? are explained specification and pharmaceutically acceptable acid addition salts prodrugs thereof either alone salt. Exemplified N-(3,5-bis-trifluoromethyl-benzyl)-N-methyl-6-( 4-methyl-piperazin-l-yl)-4-o-tolyl-nicotinamide. also pharmaceutical composition comprising one more such antagonists, excipient injury.