Mitomycin-C-induced sister-chromatid exchanges and cell-cycle kinetics in lymphocytes from patients with Klinefelter syndrome.
作者： Zentaro Yamagata , Sumio Iijima , Tatsuya Takeshita , Chiaki Ariizumi , Makoto Higurashi
DOI: 10.1016/0027-5107(89)90077-8
关键词: Aneuploidy 、 Endocrinology 、 Lymphocyte 、 Cell Cycle Kinetics 、 Klinefelter syndrome 、 Sister chromatids 、 Sister chromatid exchange 、 Internal medicine 、 Genetics 、 Biology 、 Cell cycle 、 Mitomycin C
摘要: Abstract The chromosomal sensitivity to mitomycin-C (MMC) and cell-cycle kinetics in cells from patients with Klinefelter syndrome, a sex disorders giving high risk of malignant tumor, were studied by techniques sister-chromatid exchanges (SCEs). frequencies MMC-induced SCEs increased proportion the increase MMC concentration both patient normal control cells. At low levels there no significant differences SCE between cells, but at concentrations 3 × 10 −8 M (p −7
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