Sequential liver and bone biochemical changes in hyperthyroidism: prospective controlled follow-up study

摘要: OBJECTIVE To reexamine the prevalence and sequential changes of liver bone biochemical abnormalities in patients with hyperthyroidism. METHODS A consecutive series 95 hyperthyroidism 66 controls euthyroid goiter seen during same period were studied. The treated propylthiouracil (PTU) 300 mg/day for 2 months, followed by 100-150 3 months a subsequent maintenance dose 100 mg/day. Serum aspartate amino-transferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), gamma-glutamyl transpeptidase (GGT), bilirubin, ALP isoenzymes, hepatitis markers studied before therapy at 5 after PTU was begun. RESULTS Seventy-two [75.8%, confidence interval (CI) 67.2-84.4%] had least one abnormality. AST, ALT, ALP, GGT, bilirubin elevated 27.4%, 36.8%, 64.2%, 16.8%, 5.3%, respectively. Of 34 ALT elevation, 62% showed gradual normalization whereas 38% (CI 21.9-54.5%) transient, asymptomatic, but significant (p < 0.025) further elevation therapy. Overt developed patient. None these due to A, B, C, or delta virus infection autoimmune hepatitis. Changes serum GGT parallel those ALT. In contrast, (primarily isoenzyme) rose significantly 0.01) as T4 T3 levels declined CONCLUSIONS results suggest that is often associated abnormal tests, particularly thus may pose diagnostic confusion. increase isoenzyme accounts elevations total level usually subside therapy, transient asymptomatic hepatotoxicity occurs one-third patients. Discontinuation not required unless overt develops.