Development of Strongylus vulgaris-specific serum antibodies in naturally infected foals.

摘要: Strongylus vulgaris is regarded as the most pathogenic helminth parasite infecting horses. Migrating larvae cause pronounced endarteritis and thrombosis in cranial mesenteric artery adjacent branches, thromboembolism can lead to ischemia infarction of large intestinal segments. A recently developed serum ELISA allows detection S. vulgaris-specific antibodies during six-month-long prepatent period. population horses has been maintained at University Kentucky without anthelmintic intervention since 1979, documented be highly prevalent. In 2012, 12 foals were born this population, studied a 12-month period (March-March). Weekly samples collected monitor specific with ELISA. Nine colts underwent necropsy different time points between 90 300 days age. At necropsy, spp. Parascaris equorum identified species stage enumerated. Initial statistical findings indicate significant interaction foal age results (p<0.042). All had initial evidence vulgaris-directed maternal transferred colostrum, but then remained negative their first three months life. Foals February March became positive about weeks age, while those April May went 15 21 weeks, respectively. Foal date birth was significantly associated (p<0.0001). This could explained by date-dependent differences exposure. One ELISA-negative throughout course 30 study. association found values larval burdens (p<0.0001) well three-way vulgaris, edentatus, P. (p<0.001). plateau subsequent decline corresponded leaving bloodstream migrating back intestine.