Increased risk of cognitive impairment in patients with components of metabolic syndrome.
作者： Chia-Kuang Tsai , Tung-Wei Kao , Jiunn-Tay Lee , Chen-Jung Wu , Dueng-Yuan Hueng
DOI: 10.1097/MD.0000000000004791
关键词: Obesity 、 Gerontology 、 Cognition 、 Digit symbol substitution test 、 Cognitive decline 、 Disease 、 National Health and Nutrition Examination Survey 、 Metabolic syndrome 、 Medicine 、 Dementia
摘要: The number of old adults with cognitive impairment or dementia is anticipated to increase rapidly due the aging population, especially patients multiple chronic conditions metabolic perturbation. Metabolic syndrome (Mets) among most hazardous risk factors for cardiovascular disease and linked a inflammatory disease. We investigated National Health Nutrition Examination Survey (NHANES) database years 1999 2002 explore connection between Mets decline.A total 2252 NHANES (1999-2002)-registered individuals who were stroke-free aged ≧60 enrolled in this study. This study surveyed effects existence diverse characteristics on individuals' performances as measured digit symbol substitution test (DSST).The more features achieved lower DSST scores than those fewer constituents (P 0.05).Mets was positively associated decline years. that strongly high plasma glucose elevated blood pressure.
sci-hub.se 参考文章(36)
Kristine Yaffe, Lynn Ackerson, Manjula Kurella Tamura, Patti Le Blanc, John W Kusek, Ashwini R Sehgal, Debbie Cohen, Cheryl Anderson, Lawrence Appel, Karen DeSalvo, Akinlolu Ojo, Stephen Seliger, Nancy Robinson, Gail Makos, Alan S Go, Chronic Renal Insufficiency Cohort Investigators, None, Chronic Kidney Disease and Cognitive Function in Older Adults: Findings from the Chronic Renal Insufficiency Cohort Cognitive Study Journal of the American Geriatrics Society. ,vol. 58, pp. 338- 345 ,(2010) , 10.1111/J.1532-5415.2009.02670.X
Suzanne M. De La Monte, Insulin resistance and Alzheimer's disease. Journal of Biochemistry and Molecular Biology. ,vol. 42, pp. 475- 481 ,(2009) , 10.5483/BMBREP.2009.42.8.475
Terri L. Strassburger, Hing-Chung Lee, Eileen M. Daly, Joanna Szczepanik, Jack S. Krasuski, Marc J. Mentis, Judith A. Salerno, Charles DeCarli, Mark B. Schapiro, Gene E. Alexander, Interactive Effects of Age and Hypertension on Volumes of Brain Structures Stroke. ,vol. 28, pp. 1410- 1417 ,(1997) , 10.1161/01.STR.28.7.1410
Michiaki Nagai, Satoshi Hoshide, Joji Ishikawa, Kazuyuki Shimada, Kazuomi Kario, Ambulatory blood pressure as an independent determinant of brain atrophy and cognitive function in elderly hypertension. Journal of Hypertension. ,vol. 26, pp. 1636- 1641 ,(2008) , 10.1097/HJH.0B013E3283018333
J UNGER, J LIVINGSTON, A MOSS, Insulin receptors in the central nervous system: localization, signalling mechanisms and functional aspects. Progress in Neurobiology. ,vol. 36, pp. 343- 362 ,(1991) , 10.1016/0301-0082(91)90015-S
Rebecca J. Griffin, Suzanne Timmons, Rosemary O’Connor, Rivka Ravid, Cora O’Neill, Aileen M. Moloney, Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling Neurobiology of Aging. ,vol. 31, pp. 224- 243 ,(2010) , 10.1016/J.NEUROBIOLAGING.2008.04.002
Léon H Henskens, Abraham A Kroon, Robert J van Oostenbrugge, Ed H Gronenschild, Paul A Hofman, Jan Lodder, Peter W de Leeuw, Associations of ambulatory blood pressure levels with white matter hyperintensity volumes in hypertensive patients. Journal of Hypertension. ,vol. 27, pp. 1446- 1452 ,(2009) , 10.1097/HJH.0B013E32832B5204
Ekaterina Tchistiakova, Nicole D. Anderson, Carol E. Greenwood, Bradley J. MacIntosh, Combined effects of type 2 diabetes and hypertension associated with cortical thinning and impaired cerebrovascular reactivity relative to hypertension alone in older adults. NeuroImage: Clinical. ,vol. 5, pp. 36- 41 ,(2014) , 10.1016/J.NICL.2014.05.020
Auriel A. Willette, Sterling C. Johnson, Alex C. Birdsill, Mark A. Sager, Bradley Christian, Laura D. Baker, Suzanne Craft, Jennifer Oh, Eric Statz, Bruce P. Hermann, Erin M. Jonaitis, Rebecca L. Koscik, Asenath La Rue, Sanjay Asthana, Barbara B. Bendlin, Insulin resistance predicts brain amyloid deposition in late middle-aged adults. Alzheimers & Dementia. ,vol. 11, pp. 504- 510 ,(2015) , 10.1016/J.JALZ.2014.03.011
Lenore J Launer, G.Webster Ross, Helen Petrovitch, Kamal Masaki, Dan Foley, Lon R White, Richard J Havlik, Midlife blood pressure and dementia: the Honolulu–Asia aging study☆ Neurobiology of Aging. ,vol. 21, pp. 49- 55 ,(2000) , 10.1016/S0197-4580(00)00096-8