Molecular Dynamics Simulations of Adenosine Receptors: Advances, Applications and Trends
作者： Nizar A. Al-Shar'i , Qosay A. Al-Balas
DOI: 10.2174/1381612825666190304123414
关键词: Molecular switch 、 Allosteric regulation 、 Adenosine receptor 、 G protein-coupled receptor 、 Molecular recognition 、 Signal transduction 、 Receptor 、 Drug discovery 、 Chemistry 、 Computational biology
摘要: Adenosine receptors (ARs) are transmembrane proteins that belong to the G protein-coupled receptors (GPCRs) superfamily and mediate the biological functions of adenosine. To date, four AR subtypes are known, namely A1, A2A, A2B and A3 that exhibit different signaling pathways, tissue localization, and mechanisms of activation. Moreover, the widespread ARs and their implication in numerous physiological and pathophysiological conditions had made them pivotal therapeutic targets for developing clinically effective …
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