Transgenic mouse comprising a disrupted Fibulin-4 gene as a model for cardiovascular disease
作者： Roland Kanaar , Georgios Aris Garinis , Jeroen Essers
DOI:
关键词: Genetically modified mouse 、 Biology 、 Disease 、 Cell 、 Pathology 、 Thoracic aortic aneurysm 、 Fibulin 、 Gene 、 Animal model 、 Aortic aneurysm
摘要: The invention relates to an animal model of cardiovascular disease and a method preparation use thereof. In particular, it genetically engineered aortic aneurysms methods for screening drugs using the model. Provided is genetically-modified, non-human mammal, wherein modification results in disrupted Fibulin-4 gene. Also provided genetically-modified cell containing mammal or can be used as condition disease, preferably aneurysm, more thoracic aneurysm. Furthermore, identify validating compound that treat prevent aberrant are provided, well gene involved response failure.
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