Photooxygenation of Furylalkylamines: Easy Access to Pyrrolizidine and Indolizidine Scaffolds.
作者： Dimitris Kalaitzakis , Myron Triantafyllakis , Manolis Sofiadis , Dimitris Noutsias , Georgios Vassilikogiannakis
关键词: Pyrrolizidine 、 Sequence (biology) 、 Cascade reaction 、 Indolizidine 、 Chemistry 、 Photooxygenation 、 Organic chemistry
摘要: A highly adaptable method targeting the ubiquitous and very important pyrrolizidine indolizidine scaffolds is presented. The general synthetic utility of underscored by its application to rapid easy synthesis five natural products starting from readily accessible alkylfuran precursors. These unprotected primary furylalkylamines are subjected photooxygenation conditions, which initiate a complex cascade reaction sequence concluding with production high value motifs. This can be tailored need varying choice both photosensitizer base additive.
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