Changes in the metabolome and microRNA levels in biological fluids might represent biomarkers of neurotoxicity: A trimethyltin study.

摘要: Neurotoxicity has been linked with exposure to a number of common drugs and chemicals, yet efficient, accurate, minimally invasive methods detect it are lacking. Fluid-based biomarkers such as those found in serum, plasma, urine, cerebrospinal fluid have great potential due the relative ease sampling but at present, data on their expression translation lacking or inconsistent. In this pilot study using trimethyl tin rat model central nervous system toxicity, we applied state-of-the-art assessment techniques identify individual patterns urine cerebral spinal that may be indicative nerve cell damage degeneration. Overall changes metabolites microRNAs were observed biological fluids associated neurotoxic induced by tin. Behavioral magnetic resonance imaging T2 relaxation ventricle volume served animals responded adverse effects Impact statement These will help design follow-on studies other known neurotoxicants used assess broad applicability present findings. Together approach represents an effort begin develop qualify set translational biochemical markers neurotoxicity readily accessible humans. Such could prove invaluable for drug development research ranging from preclinical clinical trials assist monitoring severity life cycle brain lesions.