Prolonged recovery and reduced adaptation in aged rat muscle following eccentric exercise

摘要: Abstract We tested the hypothesis that exposure to eccentric (lengthening) contractions results in greater damage and more prolonged recovery aged rat muscle (32 months) than adult (6 months), adaptation usually associated with a single exercise is reduced muscle. Experiments were performed using new model for aging studies, Fisher 344/Brown Norway F1 Hybrid. An ankle flexor, tibialis anterior (TA), was subjected series of 24 situ contractile function assessed 1, 2, 5 14 days following. Eccentric produced similar reduction maximum specific twitch tetanic tension muscles at 1 2 postexercise. Adult recovered by days, while TA remained significantly impaired. Aged fully restored days. Exercise subjecting second following first. Contractile determined exercise. maintained its pre-exercise force exercise, again showed significant reduction. Thus, complete TA, but not muscles.