Prognostic indicators in breast cancer--morphometric methods.

摘要: Morphometric methods were applied to predict the clinical course of individual patients with breast cancer. Measurement tumour diameter, assessment mitotic and cellular indices, quantitative microscopy nuclear features assessed together histological grades. Of tumours from 78 investigated, 42 had died metastases within 6.5 years ('non-survivors'), while other 36 alive well without evidence at end follow-up period (minimum years) ('survivors'). If non-survivors are compared those survivors, there many reproducible significant differences, most important being cellularity index activity index, followed by microscopical parameters grade. Discriminant analysis, data alone showed 82% all be correctly classified as survivor or non-survivor. By contrast axillary lymph node invasion status alone, diameter together, 59% 64% predicted With a more realistic statistical approach discriminant 78% microscopy, in place 54% status, 56% TNM-system combination TNM system Morphometry thus seems possible outcome accurately than usual staging/grading methods. This technique might therefore prove useful selection for adjuvant chemotherapy.