A case of childhood acute myeloid leukemia associated with inversion (7)(p21q31).
作者： Birgitte S. Preiss , Henrik Hasle , Anne G. Sørensen , Mogens Heil , Gitte B. Kerndrup
DOI: 10.1016/S0165-4608(98)00132-0
关键词: Lymph node 、 Myeloid leukemia 、 CD33 、 Bone marrow 、 Chromosome 7 (human) 、 Myeloid 、 Pathology 、 Biology 、 Stem cell marker 、 Immunology 、 Childhood Acute Myeloid Leukemia
摘要: We describe a case of acute myeloid leukemia in 2 1/2-year-old boy presenting with mediastinal tumor causing respiratory distress, and lymph node enlargement the cervical inguinal regions. Apart from markers CD13 CD33, blast cells also expressed stem cell marker CD34 megakaryocytic CD61. Cytogenetically, inv(7)(p21q31) was found 9/25 15/25 analyzed metaphases short-term cultures bone marrow cells, respectively. The patient is continued complete remission 26 months post diagnosis. demonstrates that chromosome aberrations other than inv(16), t(8;21), t(9;11) may be associated extramedullary disease, not all 7 are prognostic adverse findings.
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