Genes preferentially induced by depolarization after concussive brain injury: effects of age and injury severity.
作者： Christopher C. Giza , Mayumi L. Prins , David A. Hovda , Harvey R. Herschman , Jonathan D. Feldman
DOI: 10.1089/08977150252932352
关键词: Endocrinology 、 Internal medicine 、 Gene expression 、 Central nervous system disease 、 Hippocampus 、 Northern blot 、 Pathophysiology 、 Depolarization 、 Immediate early gene 、 Biology 、 Pathology 、 Traumatic brain injury
摘要: Fluid percussion (FP) brain injury leads to immediate indiscriminate depolarization and massive potassium efflux from neurons. Using Northern blotting, we examined the post-FP expression of primary response/immediate early genes previously described as induced by in brain. RNA ipsilateral contralateral hippocampus was harvested immature adult rats 1 h following mild, moderate, or severe lateral fluid compared against age-matched sham animals. C-fos gene used a positive control showed marked induction both pups (6-25-fold with increasing severity) adults (9.7-17.1-fold). Kinase-induced-by-depolarization-1 (KID-1) salt-inducible kinase (SIK) increased (KID-1 1.5-1.6-fold; SIK 1.3-3.9-fold) but not developing rats. NGFI-b elevated after ages (pups 1.8-6.1-fold; 3.5-5-fold), pattern similar that seen for c-fos. Secretogranin I (sec I) demonstrated no signif...
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