Two distinct lymphocyte populations mediate simian immunodeficiency virus envelope-specific target cell lysis

摘要: The relative contributions of the effector lymphocyte responses to AIDS virus envelope glycoprotein (env) were explored in simian immunodeficiency macaques (SIVmac)-infected rhesus monkeys. CD8+, MHC class I-restricted, env-specific CTL cloned from PBL SIVmac-infected monkeys, indicating that such cells constitute a component response. A limiting dilution 51Cr release assay was then established for quantitating frequency SIVmac-specific lymphocytes Using this we demonstrate SIVmac are comprised both CD16-, I-restricted and CD16+, I-unrestricted cells. We also response is predominant These studies document complexity establish role played by two distinct cell populations