Skin Barrier Dysfunction and the Atopic March
作者： Maja-Lisa Clausen , Tove Agner , Simon Francis Thomsen
DOI: 10.1007/S40521-015-0056-Y
关键词: Atopic sensitization 、 Atopic dermatitis 、 Medicine 、 Context (language use) 、 Skin barrier function 、 Population 、 Dermatology 、 Asthma 、 Allergy 、 Skin barrier
摘要: The atopic diseases: dermatitis, asthma and allergic rhinoconjunctivitis are frequent diseases in the population occurring sequentially young (the march). discovery of filaggrin gene (FLG) mutations impairments skin barrier as predisposing factors for dermatitis subsequent sensitization context eczema has improved our understanding march. can now be viewed upon causally related conditions—rather than manifestations same underlying disease state—with FLG being a prerequisite development other diseases, particularly asthma. This review discusses role function, mutations,
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