Decreased Expression of FADS1 Predicts a Poor Prognosis in Patients with Esophageal Squamous Cell Carcinoma.
作者： Yong Du , Shu-Mei Yan , Wan-Yi Gu , Fan He , Li-Yun Huang
DOI: 10.7314/APJCP.2015.16.12.5089
关键词: Tumor Status 、 Oncology 、 Internal medicine 、 Immunohistochemistry 、 Biomarker (medicine) 、 Cytoplasm 、 Fatty Acid Desaturase 1 、 FADS1 、 Biology 、 Fatty acid metabolism 、 Carcinogenesis
摘要: FADS1 (fatty acid desaturase 1) plays a crucial role in fatty metabolism, and it was recently reported to be involved tumorigenesis. However, the of expression esophageal squamous cell carcinoma (ESCC) remains unknown. In current study, we investigated clinical pathologic prognostic significance ESCC. Immunohistochemical analyses revealed that 58.2% (146/251) ESCC tissues had low levels expression, whereas 41.8% (105/251) exhibited high expression. positive cases, detected cytoplasm cells. Correlation demonstrated significantly correlated with tumor location (p=0.025) but not age, gender, histological grade, status, nodal status or TNM staging. Furthermore, patients tumors expressing FADS1had longer disease-free survival time (p<0.001) overall (p <0.001). Univariate multivariate that, along an independent significant predictive factor (p<0.001). conclusion, our study suggested might valuable biomarker potential therapeutic target for
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