FADS1 rs174549 Polymorphism May Predict a Favorable Response to Chemoradiotherapy in Oral Cancer Patients.

摘要: Purpose The fatty acid desaturase 1 ( FADS1 ) gene variant is a novel susceptibility marker for laryngeal squamous cell carcinoma identified by recent genome-wide association study, but it still unclear whether this genetic continues to influence oral cancer recurrence or death. purpose of study was evaluate the role rs174549 polymorphism and its interaction with postoperative chemoradiotherapy in prognosis cancer. Patients Methods A prospective cohort involving 304 patients surgical resection conducted Fujian, China. Demographic clinical data (adjuvant therapy types, histologic stage, etc.) were extracted from medical records, follow-up obtained telephone interviews. We collected 5 8 mL venous blood all DNA extraction, genotypes determined TaqMan assays (Life Technologies, Carlsbad, CA). Cox proportional hazards model Kaplan-Meier curve used assess between progression-free survival (PFS), as well overall survival, Results Carrying AA genotype significantly associated decreased risk PFS: hazard ratio 0.52 (95% confidence interval, 0.29 0.93) codominant 0.54 0.31 0.94) recessive model. Moreover, better PFS particularly obvious who had received chemoradiotherapy. positive multiplicative observed P  = .036). No significant found survival. Conclusions Our suggests, first time, that potentially independent favorable factor predicting especially undergo chemoradiotherapy, may serve potential target individualized treatment future.