A quantitative theory of reversible electrical breakdown in bilayer membranes

摘要: Abstract A quantitative theory of reversible electrical breakdown is described which allows prediction the membrane resistance R ( t ) and transmembrane potential U as a function time. The based on hypothesis large population transient aqueous pores continually present in bilayer membrane. pore probability density n r, by differential equation derived previously. Under influence an applied , will expand rapidly. For can grow so that they conduct current significantly; this revealed experimentally large, sudden drop membrane's resistance. criteria previous paper are used to determine pores' conductance. These combination with another describes circuit typical experimental apparatus. equations solved simultaneously numerical methods. version provides description essentially all key features breakdown, including avoidance pore-caused rupture for short pulses.