Modulating the bacterial surface with small RNAs: a new twist on PhoP/Q-mediated lipopolysaccharide modification.

摘要: Summary In recent years, small non-coding RNAs have emerged as important regulatory components in bacterial stress responses and virulence. Many of these are conserved related species act on target mRNAs by sequence complementarity. They tightly controlled at the transcription level, frequently elements global systems. Escherichia coli Salmonella, almost one-third functional characterized participate control outer membrane protein production. A subset genes is under sigma(E)-signalling system that monitors folding status envelope interacts with other systems to integrate multiple signals into a co-ordinated cellular response. this issue Molecular Microbiology, Moon Gottesman describe novel baseparing RNA participates modulation surface properties regulating lipopolysaccharide modification. The expressed part PhoP/PhoQ two-component plays major role virulence pathogenic species. This work expands list regulators known expression enterobacteria reinforces idea one central modulate fine-tune cell composition structure.