In vitro degradation and cell response of calcium carbonate composite ceramic in comparison with other synthetic bone substitute materials

摘要: The robust calcium carbonate composite ceramics (CC/PG) can be acquired by fast sintering at a low temperature (650 °C) using biocompatible, degradable phosphate-based glass (PG) as agent. In the present study, in vitro degradation and cell response of CC/PG were assessed compared with 4 synthetic bone substitute materials, ceramic (CC), PG, hydroxyapatite (HA) β-tricalcium phosphate (β-TCP) ceramics. rates decreasing order follows: CC, CC/PG, β-TCP, HA. proliferation rat mesenchymal stem cells (rMSCs) cultured on was comparable that CC but inferior to HA β-TCP. alkaline phosphatase (ALP) activity rMSCs lower than higher PG had enhanced gene expression specific osteogenic markers, respectively. Compared expressed relatively level collagen I runt-related transcription factor 2, showed more considerable osteopontin. Although HA, β-TCP possessed impressive performances some aspects, they faced extant intrinsic drawbacks either rate or mechanical strength. Based compressive strength, moderate rate, good response, being free obvious shortcoming, is promising another choice for materials.